• Name: Kangmin He
    • Title: Principal Investigator
    • Phone: 010-6480-6564
    • Email: kmhe@genetics.ac.cn

      Education and Appointments:

    • Education
       
      2004-2008
      BS in Health Science Center, Peking University, Beijing, China
      2008-2013
      Ph.D. in Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
       
      Employment History
       
      2013-2019
      Postdoctoral fellow/Research Associate/Instructor, Boston Children's Hospital /Harvard Medical School, Boston, USA
      2019-       
      Principle Investigator at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

      Research Direction:

    • Research Direction:
       
      Using live-cell single-molecule quantitative imaging, quantitative image analysis, genome editing, biosensor design, and other advanced tools, we investigate the spatiotemporal dynamics and regulation of membrane trafficking and phospholipid signaling..

      Representative Works:

    • Selected publications (# Co-first author; * Corresponding author)
       
      Jiachao Xu#, Yu Liang#, Nan Li#, Song Dang#, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yaran Yang, Yongtao Du, Yi Yuan, Xinyi Zhang, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He*. Clathrin-associated carriers enable recycling via a kiss-and-run mechanism. Nature Cell Biology (2024) 26:1652–1668.
       
      Jing Wang#, Zhengyang An#, Zhongsheng Wu#, Wei Zhou#, Pengyu Sun, Piyu Wu, Song Dang, Rui Xue, Xue Bai, Yongtao Du, Rongmei Chen, Wenxu Wang, Pei Huang, Sin Man Lam, Youwei Ai, Suling Liu, Guanghou Shui, Zhe Zhang, Zheng Liu, Jianyong Huang, Xiaohong Fang*, Kangmin He*. Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions. Molecular Cell (accepted).
       
      Zhongsheng Wu#, Yongtao Du#, Tom Kirchhausen*, Kangmin He*. Probing and imaging phospholipid dynamics in live cells. Life Metabolism (2024) 4(3), loae014.
       
      Yue Miao#, Yongtao Du#, Baolei Wang, Jingjing Liang, Yu Liang, Song Dang, Jiahao Liu, Dong Li, Kangmin He*, Mei Ding*. Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation. eLife (2024). doi.org/10.7554/eLife.96353.2.
       
      Jiachao Xu, Han Xiao, Kangmin He*, Youyi Zhang*. Crosstalk between adrenergic receptors and catalytic receptors. Current Opinion in Physiology (2023) 36:100718.
       
      Xue Bai#, Pengyu Sun#, Xinghao Wang#, Changkun Long#, Shuyun Liao#, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He*, Zhe Zhang*. Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discovery (2023) 9(1):18.
       
      Yi Yuan#, Xinghao Wang#, Jie Jin, Zhiheng Tang, Wei Xian, Xinyi Zhang, Jiaqi Fu*, Kangmin He*, Xiaoyun Liu*. The Salmonella Typhimurium effector SpvB subverts host membrane trafficking by targeting clathrin and AP-1. Molecular & Cellular Proteomics (2023) 22(12):100674.
       
      Guozhi Bi#, Min Su#, Nan Li#, Yu Liang, Song Dang, Jiachao Xu, Meijuan Hu, Jizong Wang, Minxia Zou, Yanan Deng, Qiyu Li, Shijia Huang, Jiejie Li, Jijie Chai*, Kangmin He*, Yu-Hang Chen*, Jian-Min Zhou*. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Cell (2021) 184(13):3528-3541.
       
      Kangmin He#, Eli Song#, Srigokul Upadhyayula#, Song Dang, Raphael Gaudin, Wesley Skillern, Kevin Bu, Benjamin R. Capraro, Iris Rapoport, Ilja Kusters, Minghe Ma, Tom Kirchhausen. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. Journal of Cell Biology (2020) 219(3) pii: e201908142.
       
      Kangmin He*, Robert Marsland III, Srigokul Upadhyayula, Eli Song, Song Dang, Ben Capraro, Weiming Wang, Wesley Skillern, Raphael Gaudin, Minghe Ma, Tom Kirchhausen*. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. Nature (2017) 552:410-414.
       
      Nan Li, Rong Zhao, Yahong Sun, Zi Ye, Kangmin He*, Xiaohong Fang*. Single-molecule imaging and tracking of molecular dynamics in living cells. National Science Review (2017) 4:739–760.
       
      Kangmin He, Xiaohua Yan, Nan Li, Song Dang, Li Xu, Bing Zhao, Zijian Li, Zhizhen Lv, Xiaohong Fang*, Youyi Zhang*, Ye-Guang Chen*. Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes. Cell Research (2015) 25:738-752.
       
      Kangmin He, Rui Xing, Xiaohua Yan, Aiju Tian, Mingliang Zhang, Jinghe Yuan, Zhizhen Lv, Xiaohong Fang, Zijian Li*, Youyi Zhang*. mAbp1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction. FASEB Journal (2015) 29:2495-503.
       
      Kangmin He, Xiaoli Shi, Xuejie Zhang, Song Dang, Xiaowei Ma, Fei Liu, Ming Xu, Zhizheng Lv, Dong Han, Xiaohong Fang*, Youyi Zhang*. Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes. Cardiovascular Research (2011) 92:39–47.
       
      Kangmin He#, Wangxi Luo#, Yuliang Zhang, Fei Liu, Da Liu, Li Xu, Lei Qin, Chunyang Xiong, Zhizhen Lu, Xiaohong Fang*, Youyi Zhang*. Intercellular transportation of quantum dots mediated by membrane nanotubes. ACS nano (2010) 4:3015-3022.
       
      Yi-Ying Chou#, Srigokul Upadhyayula#,*, Justin Houser, Kangmin He, Wesley Skillern, Gustavo Scanavachi, Song Dang, Anwesha Sanyal, Kazuka G. Ohashi, Giuseppe Di Caprio, Alex J.B. Kreutberger, Tegy John Vadakkan, Tom Kirchhausen*. Inherited nuclear pore substructures template post-mitotic pore assembly. Developmental Cell (2021) 56:1786-1803.e9.
       
      Frederick B Shipley#, Neil Dani#, Huixin Xu, Christopher Deister, Jin Cui, Joshua P Head, Cameron Sadegh, Ryann M Fame, Morgan L Shannon, Vanessa I Flores, Thomas Kishkovich, Emily Jang, Eric M Klein, Glenn J Goldey, Kangmin He, Yong Zhang, Michael J Holtzman, Tomas Kirchhausen, Claire Wyart, Christopher I Moore, Mark L Andermann*, Maria K Lehtinen*. Tracking calcium dynamics and immune surveillance at the choroid plexus blood-cerebrospinal fluid interface. Neuron (2020) S0896-6273(20)30655-3.
       
      Yu Hu#, Ji Hyung Kim#, Kangmin He, Qi Wan, Jessica Kim, Melanie Flach, Tom Kirchhausen, Andrea Vortkamp, Florian Winau*. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. Journal of Experimental Medicine (2016) 213:2759-2772.
       
      Francois Aguet#, Srigokul Upadhyayula#, Raphael Gaudin#, Yi-ying Chou, Emanuele Cocucci, Kangmin He, Bi-Chang Chen, Kishore Mosaliganti, Mithun Pasham, Wesley Skillern, Wesley R. Legant, Tsung-Li Liu, Greg Findlay, Eric Marino, Gaudenz Danuser, Sean Megason, Eric Betzig, Tom Kirchhausen*. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Molecular Biology of the Cell (2016) 27:3418-3435.