CAS
中文
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- Name： Youwei Ai
- Title： Principal Investigator
- Email： aiyouwei@genetics.ac.cn
- Education2008-2012B.S. Northeast Forestry University, Harbin, China2012-2016Ph.D. Northeast Forestry University, Harbin, China2012-2014Ph.D. Harbin Veterinary Institute, Chinese Academy of Agricultural Sciences2014-2016Ph.D. National Institute of Biological Sciences, Beijing, ChinaEmployment History2016-2021
Postdoctoral Research Fellow in the lab of Prof. Xiaodong Wang,
National Institute of Biological Sciences, Beijing, China,
&Tsinghua University, Beijing, China.
2021-Principle Investigator at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. - Programmed cell death (PCD), unlike apparently accidental cell death, refers to a cell death process that is genetically regulated. PCD is critically involved in growth, development, and homeostasis in a large variety of specific situations. Thus, understanding the biochemical mechanisms and implications of PCD under physiological or pathological situations can help us to intervene or cure diseases caused by suppressed or overactivated cell death, like killing tumor, preventing infectious disease, or neurodegeneration, ect.
- Publications as PI（# First author; * Corresponding author）1) Buhao Deng#, Jingyi Wang#, Tingyun Yang#, Zhao Deng#, Jiafan Yuan, Bohan Zhang, Zhen Zhou, Fang Chen, Lu Fang, Chengzhi Liang, Bo Yan*, Youwei Ai*. TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression. (2024), Journal of Cell Biology, vol. 223 no. 3. https://doi.org/10.1083/jcb.202305026.2) Youwei Ai, Yutong Meng, Bo Yan, Qinyi Zhou, Xiaodong Wang*. The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death. (2024), Molecular Cell, https://doi.org/10.1016/j.molcel.2023.11.040. (Invited Review)3) Bo Yan#, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai*. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. (2022), Cell Chemical Biology 29 (6), 958-969.e5---Commented by Heidi Greulich (Broad Institute) in Cell Chemical Biology: A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation.Publications as PhD/post-doc（# First author; * Corresponding author）1) Bo Yan#*, Youwei Ai#*, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. (2021). Molecular Cell 81 (2), 355-369. e10 (Lead Contact)---Recommended by Faculty Opinions (F1000Prime) (10.3410/f.739220181.793581481)---Highlighted by Nature Chemical Biology.---Commented by Protein & Cell.2) Bo Yan, Youwei Ai*, Zhiyuan Zhang, Xiaodong Wang*. Assessing POR and CYB5R1 oxidoreductase-mediated oxidative rupture of PUFA in liposomes. (2021). STAR Protocols 2 (1), 1003603 Youwei Ai#, Bo Yan#, Xiaodong Wang*. The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis. (2021). Molecular & Cellular Oncology 8 (2), 1881393---Invited commentary from Dr. Guido Kroemer.4) Youwei Ai*#, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma*, Shuanhu Gao*, Xiangbing Qi*. An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. (2020). Nature Communications 11 (1), 1-10 (Lead Contact)5) Dianrong Li#, Youwei Ai#, Jia Guo, Baijun Dong, Lin Li, Gaihong Cai, She Chen, Dan Xu, Fengchao Wang, Xiaodong Wang*. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-Interacting kinase 3.(2020). eLife 9, e615646) Dianrong Li#, Jie Chen#, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbin Qi, Xiaodong Wang*. Estrogen-related hormones induce apoptosis by stabilizing Schlafen-12 protein turnover.(2019). Molecular Cell 75 (6), 1103-1116. e97) Youwei Ai*#, Jianzhang Ma*, Xiaojun Wang*. Clues for two-step virion infectivity factor regulation by core binding factor beta.(2017). The Journal of General Virology 98 (5), 11138) Youwei Ai*#, Jianzhang Ma*. Multiple lysines combined in HIV-1 Vif determines the responsiveness to CBF-β. (2015). Biochemical and Biophysical Research Communications 457 (3), 385-3909) Youwei Ai#, Dantong Zhu, Cuihui Wang, Chao Su, Jian Ma, Jianzhang Ma*, Xiaojun Wang*. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. (2014). Journal of Virology 88 (20), 12112-12122
Faculty
