Xiang Li

 

Our lab focuses on the development of single cell omic technology, to investigate the genetic and molecular mechanism of cell fate decision in photosynthesis.

 

1. Development of single cell omic technology. Single cell technology revolutionized whole-organism science, thoroughly dissecting the cell fate decision and development. Our team works in developing single cell omics, subcellular omics, and in-situ sequencing technology, through cooperating or recruiting researchers associated with nanomaterial and precision instrument.

 

2. Investigation of cell fate decision in C3-C4 photosynthesis. Photosynthesis converts luminous energy into chemical energy and provides oxygen for biosphere, which is, therefore, one of the most important research fields in plant science. Many scientific questions were still not answered, and our team will try to figure out them by integrating new technologies and strategies.

 

1. Ma Y, Gou B, Xu Y, Li X. Embryo spatial 3D genomics, bioRxiv, https://doi.org/10.1101/2024.05.07.592900.

2. 李响，屠瑜璐，顾剑辉。一种禾本科 PACMAD 类群 HB 基因及其在作物增产、抗高温中的用途。中国，202410648111.7（受理）

3. 李响，马宇昂。一种空间多维组学机器人自动实验系统。中国，202410589894.6（受理）

4. 李响，马宇昂，苟博。一种基于微流控芯片的空间三维基因组学测序方法及其应用。中国，202410017141.8（受理）

5.Jiang C, Sun J, Li R, Yan S, Chen W, Guo L, Qin G, Wang P, Luo C, Huang W, Zhang Q, Fernie AR, Jackson D,Li X^*, Yan J^*. A reactive oxygen species burst causes haploid induction in maize.Mol. Plant.15, 943-955 (2022).

6.Luo C^#,Li X^#*, Zhang Q, Yan J^*. Single Gametophyte Sequencing Reveals that Crossover Events Differ between Sexes in Maize.Nat. Commun.10, 785 (2019).

7.Li X^#, Chen L^#, ZhangQ, SunY, Li Q^*, Yan J^*.BRIF-seq: bisulfite-converted randomly integrated fragments sequencing at single cell level.Mol. Plant.12, 438-446 (2019).

8.Li X^#, Meng D^#, Chen S, Luo H, Zhang Q, Jin W, Yan J. Single nucleus sequencing reveals spermatid chromosome fragmentation as a possible cause of maize haploid induction.Nat. Commun.8, 991 (2017).

9.Liu C^#,Li X^#, Meng D^#, Zhong Y, Chen C, Dong X, Xu X, Chen B, Li W, Li L, Tian X, Zhao H, Song W, Luo H, Zhang Q, Lai J, Jin W, Yan J, Chen S. A 4-bp Insertion at ZmPLA1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize.Mol. Plant.10, 520-522 (2017).

10.Li X, Li L, Yan J. Dissecting meiotic recombination based on tetrad analysis by single-microspore sequencing in maize.Nat. Commun.6, 6648 (2015).

11. Wen W^#, Li D^#,Li X, Gao Y, Li W, Li H, Liu J, Liu H, Chen W, Luo J & Yan J. Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights.Nat. Commun.5, 3438 (2014).

12. 严建兵，李响，姜程淋。一种单倍体诱导剂及其使用方法。中国，202010162970.7（授权）

13. 严建兵，姜程淋，李响。单倍体诱导基因的应用。中国，202210211369.1（授权）

 

(^#Co-first author, *Corresponding author)