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Youwei Ai
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Research Area :
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| Education
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2008-2012 |
B.S. Northeast Forestry University, Harbin, China |
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2012-2016 |
Ph.D. Northeast Forestry University, Harbin, China |
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2012-2014 |
Ph.D. Harbin Veterinary Institute, Chinese Academy of Agricultural Sciences |
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2014-2016 |
Ph.D. National Institute of Biological Sciences, Beijing, China |
Employment History
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2016-2021 |
Postdoctoral Research Fellow in the lab of Prof. Xiaodong Wang, National Institute of Biological Sciences, Beijing, China, &Tsinghua University, Beijing, China. |
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2021- |
Principle Investigator at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. |
Programmed cell death (PCD), unlike apparently accidental cell death, refers to a cell death process that is genetically regulated. PCD is critically involved in growth, development, and homeostasis in a large variety of specific situations. Thus, understanding the biochemical mechanisms and implications of PCD under physiological or pathological situations can help us to intervene or cure diseases caused by suppressed or overactivated cell death, like killing tumor, preventing infectious disease, or neurodegeneration, ect.
Publications as PI
（# First author; * Corresponding author）
1) Bo Yan#, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai*. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. (2022), Cell Chemical Biology 29 (6), 958-969.e5 ( IF 9.039/Q1)
Publications as PhD/post-doc
（# First author; * Corresponding author）
---Highlighted in Nature Chemical Biology.
---Commented in Protein & Cell.
---Invited commentary from Dr. Guido Kroemer.
4) Youwei Ai*#, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma*, Shuanhu Gao*, Xiangbing Qi*. An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. (2020). Nature communications 11 (1), 1-10 ( Lead Contact)
5) Dianrong Li#, Youwei Ai#, Jia Guo, Baijun Dong, Lin Li, Gaihong Cai, She Chen, Dan Xu, Fengchao Wang, Xiaodong Wang*. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-Interacting kinase 3.(2020). eLife 9, e61564
6) Dianrong Li#, Jie Chen#, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbin Qi, Xiaodong Wang*. Estrogen-related hormones induce apoptosis by stabilizing Schlafen-12 protein turnover.(2019). Molecular Cell 75 (6), 1103-1116. e9
9) Youwei Ai#, Dantong Zhu, Cuihui Wang, Chao Su, Jian Ma, Jianzhang Ma*, Xiaojun Wang*. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. (2014). Journal of Virology 88 (20), 12112-12122 |
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