Xun Huang

BS: Xiamen University

MS: Institute of Microbiology, Chinese Academy of Sciences

PhD: University of California at Santa Cruz

Postdoc: Stanford University

 

The long-term goal of our laboratory is to understand the regulating mechanisms of lipid metabolism and disease. Currently the main interest of our lab is to understand the cell biology and developmental biology of lipid metabolism under normal physiological conditions and under disease conditions.

 

1) The coordination of lipogenesis and lipolysis;

2) The regulation of lipid droplet growth and fusion.

 

1) The regulation of key lipid biosynthetic enzymes.

2) Coordination among lipid uptake, different biosynthetic pathways, and lipid metabolism/catabolism during development.

 

1) Lipid metabolic defects and developmental abnormality.

2) The mechanism of lipid metabolism-related diseases.

3) The developmental regulation of neuron development.

 

 

 

Staff member:

Dr. Jiesi Xu; Ms. Xia Li; Ms. Wei Wang; Dr. Haitao Wang

 

PhD Student:

Yifan Zhou, 2018-

Meng Diao, 2019-

Yang Jiao, 2019-

Honggang Su, 2020-

Yaqiang Liu, 2020-

Wei Meng, 2021-

Jianxin Zhang, 2021-

Yudie Ding, 2023-

 

Haiyang Chen (PhD 2005-2010); Yanhui Xiang (PhD 2006-2010); Zhiguo Ma (PhD 2005-2011); Chao Wang (PhD 2004-2011); Liqiang Zhang (Postdoc 2009-2010); Yuan Tian (PhD 2006-2012); Song Song (PhD 2006-2012); Qinlan Ge (PhD 2008-2012); Yuan Liu (PhD 2008-2014); Junfeng Bi (PhD 2007-2014); Jinbo Wang (PhD 2007-2015); Zhenglong Liu (PhD 2009-2016); Wei Fan (PhD 2010-2017); Long Ding (PhD 2011-2018); Yan Yao (PhD 2011-2018); Zhonghua Liu (Staff 2006-2018); Xiao Yang (PhD 2014-2019); Xing Su (Master 2015-2019); Leilei Yang (PhD 2013-2019); Xuefan Zhao (PhD 2013-2020); Mengyao Xu (PhD 2014-2021); Yuan Ji (Master 2017-2022); Huimin Pan (PhD 2015-2022); Jinglin Zhu (PhD 2016-2022); Siyu Chen, (PhD 2017-2023)

20. Chen, S., Su, X., Zhu, J., Xiao, L., Cong, Y., Yang, L., Du, Z. and Huang, X.^# (2023) Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis. EMBO Reports 24:e57440 PMID: 37885348

 

19. Pan, H., Qin, Y., Zhu, J., Wang, W., Liu, Z., Huang, X., Lam, S-M., Shui, G., Wang, Y., Jiang, Y. and Huang, X.^# (2023) Centrins control chicken cone cell lipid droplet dynamics through lipid droplet-localized SPDL1. Developmental Cell 58: 2528-2544 PMID: 37699389

 

18. Xu, J.^{*, #}, Liu, Z.^*, Zhang, J., Chen, S., Wang, W., Zhao, X., Zhen, M. and Huang, X.^# (2023) N-end rule-mediated proteasomal degradation of ATGL promotes lipid storage. Diabetes 72:210-222 PMID: 36346641

 

17. Zhu, J., Lam, S-M., Yang, L., Liang, J., Ding, M., Shui, G. and Huang, X.^# (2022) Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency. Life Metabolism 1:175-189

 

16. Zhao, X., Wang, W., Yao, Y., Li, X., Huang, X., Wang, Y., Ding, M. and Huang, X.^# (2022) An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase. EMBO Reports 23:e52669 PMID: 35132760

 

15. Xu, J.^{*, #}, Chen, S.^*, Wang, W., Lam, S-M., Xu, Y., Zhang, S., Pan, H., Liang, J., Huang, X., Wang, Y., Li, T., Jiang, Y., Wang, Y., Ding, M., Shui, G., Yang, H. and Huang, X.^# (2022) Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis.Science Bulletin 67:299-314 PMID: 36546079

 

14. Xu, M., Ding, L., Liang, J., Yang, X., Liu, Y., Wang, Y., Ding, M. and Huang, X.^# (2021) NAD kinase sustains lipogenesis and mitochondrial metabolism through fatty acid synthesis. Cell Reports 37:110157 PMID: 34965438

 

13. Yang, L., Liang, J., Lam, S-M., Yavuz, A., Shui, G., Ding, M. and Huang, X.^# (2020) Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. EMBO Reports 21:e50214 PMID: 33034119

 

12. Chen, L. ^#, Chen, X.W. ^#, Huang, X. ^#, Song, B.L. ^#, Wang, Y. ^#, Wang, Y. ^# (2019) Regulation of glucose and lipid metabolism in health and disease. Sci China Life Sci. 62:1420-1458 PMID: 31686320 (Review)

 

11. Yang, X., Liang, J., Ding, L., Li, X., Lam, S-M., Shui, G., Ding, M. and Huang, X.^# (2019) Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLoS Genetics 15:e1008548 PMID: 31869331

 

10. Yao, Y., Li, X., Wang, W., Liu, Z., Chen, J., Ding, M. and Huang, X.^# (2018) MRT, functioning with NURF complex, regulates lipid droplet size. Cell Reports 24:2972-2984 PMID: 30208321

 

9. Ding, L., Yang, X, Tian, H., Liang, J., Zhang, F., Wang, G, Wang, Y., Ding, M., Shui, G and Huang, X.^# (2018) Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 37:e97572 PMID: 30049710

 

8. Zhao, Y.^*, Luo, L.^*, Xu, J.^*, Xin, P., Guo, H., Wu, J., Bai, L., Wang, G., Chu, J., Zuo, J., Yu, H.^#, Huang, X.^# and Li, J^# (2018) Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana. Cell Research 28:448-461 PMID: 29540758

 

7. Fan, W., Lam, S-M., Xin, J., Yang, X., Liu, Z., Liu, Y., Wang, Y., Shui, G. and Huang, X.^# (2017) Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. PLoS Genetics 13:e1006664 PMID: 28273089

 

6. Bi, J., Wang, W., Liu, Z., Huang, X., Jiang, Q., Liu, G., Wang, Y. and Huang, X.^# (2014) Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA. Cell Metabolism 19:861-871 PMID: 24807223

 

5. Liu, Y., Wang, W., Shui, G.^# and Huang, X.^# (2014) CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. PLoS Genetics 10:e1004172 PMID: 24603715

 

4. Bi, J.^*, Xiang, Y.^*, Chen, H., Liu, Z., Gronke, S., Kuhnlein, R. and Huang, X.^# (2012) Opposite and redundant roles of the two Drosophila Perilipins in lipid mobilization. Journal of Cell Science 125:3568-77 PMID: 22505614

 

3. Tian, Y., Bi, J., Shui, G., Liu, Z., Xiang, Y., Liu, Y., Wenk, M., Yang, H. and Huang, X.^# (2011) Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid droplet formation. PLoS Genetics 7:e1001364 PMID: 21533227

 

2. Ma, Z., Liu, Z. and Huang, X.^# (2010) OSBP- and FAN- mediated sterol requirement for spermatogenesis in Drosophila. Development 137:3775-3784 PMID: 20943709

 

1. Chen, H., Liu, Z. and Huang, X.^# (2010) Drosophila models of peroxisomal biogenesis disorder: Peroxins are required for spermatogenesis and very long chain fatty acid metabolism. Human Molecular Genetics 19:494-505 PMID: 19933170

 

 

49. Guo, T., Miao, C., Liu, Z., Duan, J., Ma, Y., Zhang, X., Yang, W., Xue, M., Deng, Q., Guo, P., Xi, Y., Yang, X., Huang, X. and Ge, W. (2024) Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia JMCB in press

 

48. Sun, S., Zhao, G., Jia, M., Jiang, Q., Li, S., Li, W., Wang, Y., Bian, X.^#, Zhao, Y.^#, Huang, X.^#, Yang, G.^#, Cai, H.^#, Pastor-Pareja, J.^#, Ge, L.^#, Zhang, C.^# and Hu, J.^# (2023) Stay in touch with the endoplasmic reticulum. Sci. China Life Sci. in press

 

47. Zhu, J., Meng, W., Lam, S-M., Shui, G. and Huang, X.^# (2023) Phosphatidylcholine deficiency increases ferroptosis susceptibility in the C. elegans germline. J. Genetics and Genomics 50:318-329 PMID: 36933794 (Cover story)

 

46. Chen, X., Li, J., Gao, Z., Yang, Y., Kuang, W., Dong, Y., Chua, G., Huang, X., Jiang, B., Tian H., Wang, Y., Huang, X., LI, Y., Lam, S-M. ^#, and Shui, G.^# (2022) Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. National Science Review 9: nwac148 PMID: 36713590

 

45. Lam, S-M., Huang, X.^# and Shui, G.^# (2022) Neurological aspects of SARS-CoV-2 infection – Lipoproteins and exosomes as Trojan horses. Trends in Endocrinology and Metabolism 33:554-568 PMID: 35613979 (Review)

 

44. Zhu, J. and Huang, X. (2022) Endocrine function of pheromones couples fat rationing and nutrient scarcity. Sci China Life Sci. 65:1267-1269 PMID: 35266111 (Highlight)

 

43. Yao, Y., Xu, M., Qiao, L., Nie, H., Lu, F. and Huang, X.^# (2022) BAP60 plays an opposite role to the MRT-NURF complex in regulating lipid droplet size. J. Genetics and Genomics 49:377-379 PMID: 35196573

 

42. Huang, X.^#, Lin, X., Liu, F., Wu, G., Yang, Z. and Meng, A. (2022) The rise of developmental biology in China. Development Growth and Differentiation 64:106-115 PMID: 34510425

 

41. Chen, S. and Huang, X.^# (2022) Cytosolic lipolysis in non-adipose tissues: energy provision and beyond. FEBS J 289 : 7385–7398 PMID: 34407292 (Invited Review)

 

40. 刘叶阳^*, 许梦瑶^*, 李蓬, 黄勋^#, 徐俐^# (2022) 脂滴与其它细胞器互作调控脂稳态的分子机制。中国科学: 生命科学52: 76-94 (Review)

 

39. Mak, HY.^*, Ouyang, Q.^*, Tumanov, S.^*, Xu, J., Rong, P., Dong, F., Lam, S-M., Wang, X., Lukmantara, I., Du, X., Gao, M., Brown, A., Gong, X., Shui, G., Stocker, R., Huang, X., Chen, S. and Yang, H.^# (2021) AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nature Communications 12:6877 PMID: 34824276

 

38. Tan, S., Ma, H., Wang, J., Wang, M., Wang, M., Yin, H., Zhang, Y., Zhang, X., Shen J., Wang, D., Banes, G., Zhang, Z., Wu, J., Huang, X., Chen, H., Ge, S., Chen, C. and Zhang YE.^# (2021) DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans. Nature Communications 12:4280 PMID: 34257290

 

37.王海涛^#, 李亭亭, 黄勋, 马润林^#, 刘秋月^# (2021) Application of genetic modification technologies in molecular design breeding of sheep/遗传修饰技术在绵羊分子设计育种中的应用。Yi Chuan (遗传) 43:6, 580-600 PMID: 34284989 (Review)

 

36. Xu, J.^# and Huang, X. ^# (2020) Lipid metabolism at membrane contacts: dynamics and functions beyond lipid homeostasis. Frontiers in Cell and Developmental Biology 8:615856 PMID: 33425923 (Review)

 

35. Guan, L.^#, Zhan, Z., Yang, Y., Miao, Y., Huang, X., and Ding, M.^# (2020) Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons. PLoS Genetics 16:e1008704 PMID: 32986702

 

34. Yao, Y.^#, Ding, L.^# and Huang, X.^# (2020) Diverse functions of lipids and lipid metabolism in development. Small Methods 4:1900564 (Review)

 

33. Xu, Y., Mak, HY., Lukmantara, I., Li, YE., Hoehn, KL., Huang, X., Du, X. and Yang, H.^# (2019) CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. J Biol Chem. 294:16740-16755 PMID: 31548309

 

32. Gao, M., Huang, X., Song, BL., and Yang, H.^# (2019) The biogenesis of lipid droplets: Lipids take center stage. Prog Lipid Res. 75:100989 PMID: 31351098 (Review)

 

31. Huang, X. and Jin, Y. (2019). EOR-1 and EOR-2 act independently of RAS and WNT signaling pathways in RMED/V neuron specification. microPublication Biology 000140

 

30. Huang, X. and Jin, Y. (2019). New mutants defective in RMED/V neuron specification are alleles of EOR-1 and EOR-2. microPublication Biology 000139

 

29. Huang, X. and Jin, Y. (2019). EOR-1 and EOR-2 function in RMED/V neuron specification. microPublication Biology 000138

 

28. Liu, Y., Ji, Y., Li, X., Shui, G. and Huang, X.^# (2019) Lipid storage regulator CdsA is essential for Drosophila metamorphosis. J. Genetics and Genomics 46:231-234 PMID: 31072795

 

27. Wang, W.^*, Xin. J.^*, Yang, Y.^*, Lam, S-M., Shui, G. ^#, Wang. Y^# and Huang, X.^# (2019) Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. BBA-Molecular and Cell Biology of Lipids 1864:168-180 PMID: 30521938

 

26. Zhan, N., Wang, C., Chen, L., Yang, H., Feng, J., Gong, X., Ren, B., Wu, R., Mu, J., Li, Y., Liu, Z., Zhou, Y., Peng, J., Wang, K., Huang, X., Xiao, S and Zuo, J.^# (2018) S-Nitrosylation targets GSNO reductase for selective autophagy during hypoxia responses in plants. Molecular Cell 71:142-154 PMID: 30008318

 

25. Chitturi, J., Hung, W., Rahman, AMA., Wu, M., Lim, MA., Calarco, J., Baran, R., Huang, X., Dennis, JW. and Zhen, M.^# (2018) The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans. PLoS Genetics 14:e1007303 PMID: 29649217

 

24. Lam, S-M., Wang, Z., Li, J., Huang, X. and Shui, G.^# (2017) Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival. Redox Biology 12:967-977 PMID: 28499251

 

23. Tan, S., Cardoso-Moreira, M., Shi, W., Zhang, D., Huang, J., Mao, Y, Jia, H., Zhang, Y., Chen, C., Shao, Y., Leng, L., Liu, Z., Huang, X., Long, M. and Zhang, YE.^# (2016) LTR retrotransposons create transcribed retrocopies in metazoans. Genome Research. 26:1663-1675 PMID: 27934698

 

22. Pagac, M., Cooper, DE., Qi, Y., Lukmantara, IE., Mak, HY., Wu, Z., Tian, Y., Liu, Z., Lei, M., Du, X., Ferguson, C., Kotevski, D., Sadowski, P., Chen, W., Boroda, S., Harris, TE., Liu, G., Parton, RG., Huang, X., Coleman, RA. and Yang, H.^# (2016) SEIPIN regulates lipid droplet expansion and adipocyte development by modulating the activity of glycerol-3-phosphate acyltransferase. Cell Reports 17:1546-1559 PMID: 27806294

 

21. Zhang, B.^#, Chen, X., Huang, X.^# and Yang, X.^# (2016) Research advances on animal genetics in China in 2015. Yi Chuan (遗传) 38:467-507 PMID: 27655312 (Review)

 

20. Qi, Y., Kapterian T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I. and Yang, H.^# (2016) CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research 57:767-80 PMID: 26946540

 

19. Wang, J., Chitturi, J., Ge, Q., Laskova, V., Wang, W., Li X., Ding, M., Zhen, M.^# and Huang, X.^# (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457 PMID: 25790851

 

18. Huang, X.^# (2015) A lipid pathway for heat adaptation. Sci China (Life Sciences) 58:727-728 PMID: 26044402

 

17. Liu, Z., Li, X., Ge, Q., Ding, M. and Huang, X.^# (2014) A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans. J. Genetics and Genomics 41:305-313 PMID: 24894357

 

16. Zhang, J., Li, X., Jevince, A., Guan, L., Wang, J., Hall, D., Huang, X.^# and Ding, M.^# (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics 9:e1003618 PMID: 23825972

 

15. Liu, Z. and Huang, X.^# (2013) Lipid metabolism in Drosophila: development and disease. Acta Biochim Biophys Sin. 45:44-50 PMID: 23257293 (Review)

 

14. Ma, Z., Liu, Z. and Huang, X.^# (2012) Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Genetics 190:1299-1308 PMID: 22234859

 

13. Zhou, B., Yang, L., Li, S., Huang, J., Chen, H., Hou, L., Wang, J., Green, C., Yan, Z., Huang, X., Kaeberlein, M., Zhu, L., Xiao, H., Liu, Y. and Han, J.^# (2012) Midlife gene expressions identify modulators of aging through dietary interventions. PNAS 109:E1201-9 PMID: 22509016

 

12. Wang, C. and Huang, X.^# (2012) Lipid metabolism and Drosophila sperm development. Sci China (Life Sciences) 55:35-40 PMID: 22314489 (Review)

 

11. Wang, C., Liu, Z. and Huang, X.^# (2012) Rab32 is important for autophagy and lipid storage in Drosophila. PLoS One 7:e32086 PMID: 22348149

 

10. Zhang, P., Na, H., Liu, Z., Zhang, S., Xue, P., Chen, Y., Pu, J., Peng, G., Huang, X., Yang, F., Xie, Z., Xu, T., Xu, P., Ou, G., Zhang, S. and Liu, P.^# (2012) Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets. Molecular and Cellular Proteomics 11:317-28 PMID: 22493183

 

9. Yue, W., Wang, H., Sun, L., ……Huang, X., Lv, L., Li, T., Zhao, G., Huang, W., Zhang, X., and Zhang D.^# (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nature Genetics 43:1228-1231 PMID: 22037552

 

8. Wang, C., Ma, Z. Scott, M. P. and Huang, X.^# (2011) The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Developmental Biology 351:146-155 PMID: 21215267

 

7. Tuxworth, RI., Chen, H., Vivancos, V., Carvajal, N., Huang, X. and Tear G.^# (2011) The Batten disease gene CLN3 is required for the response to oxidative stress. Human Molecular Genetics 20:2037-47 PMID: 21372148

 

6. Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T., Lin, R., Dawes, I., Brown, A., Li, P., Huang, X., Parton, R., Wenk, M., Walther, T. and Yang, H.^# (2011) A role for phosphatidic acid in the formation of “supersized” lipid droplets. PLoS Genetics 7:e1002201 PMID: 21829381

 

5. Song, S., Ge, Q., Wang, J., Chen, H., Tang, S., Bi, J., Li, X., Xie, Q. and Huang, X.^# (2011) TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance. J. Genetics and Genomics 38:1-11 (Cover story) PMID: 21338947

 

4. Xiang, Y., Liu, Z. and Huang, X.^# (2010) br regulates the expression of the ecdysone biosynthesis gene npc1. Developmental Biology 344:800-808 PMID: 20621708

 

3. Song, S., Zhang, B., Sun, H., Li, X., Xiang, Y., Liu, Z., Huang, X.^# and Ding, M.^# (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6:e1001056. PMID: 20711352

 

2. Chen, H., Ma, Z., Liu, Z., Tian,Y., Xiang, Y., Wang, C., Scott, M. P. and Huang, X.^# (2009) Case studies of Ends-Out gene targeting in Drosophila. Genesis 47:305-308 PMID: 19298016

 

1. Huang, X.^#, Warren, J. and Gilbert, L.^# (2008) New players in the regulation of ecdysone biosynthesis. J. Genetics and Genomics 35:1-10 PMID: 18222403 (Review)

 

8. Abrams, B., Grill, B., Huang, X. and Jin, Y.^# (2008) Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions. Developmental Dynamics 237:630-639 PMID: 18224716

 

7. Huang, X., Warren, J., Buchanan, J. A., Gilbert, L. and Scott, M. P.^# (2007) Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Development 134:3733-3742 PMID: 17804599

 

6. Huang, X., Suyama, K., Buchanan, J. A., Zhu, AJ. and Scott, M. P.^# (2005) A Drosophila model of the Niemann-Pick Type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development 132:5115-5124 PMID: 16221727

 

5. Nakata, K., Abrams, B.,Grill, B., Goncharov, A., Huang, X., Chisholm, A.D. and Jin, Y.^# (2005) Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell 120:407-420 PMID: 15707898

 

4. Huang, X., Powell-Coffman, J. A. and Jin, Y.^# (2004). The AHR-1 aryl hydrocarbon receptor and its cofactor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans. Development 131:819-828 PMID: 14757639

 

3. Huang, X., Huang, P., Robinson, M., Stern, M. and Jin, Y.^# (2003). UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans. Development 130:3147-3161 PMID: 12783787

 

2. Huang, X., Cheng, H-J., Tessier-Lavigne, M. and Jin, Y.^# (2002). MAX-1, a novel PH/Myth4/FERM domain cytoplasmic protein implicated in Netrin-mediated axon repulsion. Neuron 34:563-576 PMID: 12062040

 

1. Zhen, M.,* Huang, X.,* Bamber, B. and Jin, Y.^# (2000). Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a Ring-H2 finger domain. Neuron 26:331-343 (* co-first author) PMID: 10839353