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  Location: Home >> Key Laboratories >> State Key Laboratory of Plant Cell and Chromosome Engineering (PCCE)
State Key Laboratory of Plant Cell and Chromosome Engineering (PCCE)
The State Key Laboratory of Plant Cell and Chromosome Engineering (PCCE) was founded in 1989. The mission of PCCE is: 1) to systematically study the genetic basis of important agronomic traits of major crops and to identify key genes involved; 2) to develop efficient gene transfer strategies in plant utilizing chromosome engineering and molecular breeding tools for designing crop varieties through the assembly elite genes or alleles; and 3) to create novel germplasms and to breed crop varieties with excellent agronomic traits, such as high yield, superior quality, high nutrient efficiency and improved tolerance to biotic and abiotic stresses.
 
HOME PAGE: http://pcce.genetics.cas.cn
DIRECTOR: Hongqing Ling
VICE DIRECTORS: Xiangdong Fu, Fangpu Han, Dingzhong Tang
PRINCIPAL INVESTIGATORS: Huabang Chen, Caixia Gao, Junming Li, Yunhai Li, Zhensheng Li, Cuimin Liu, Xigang Liu, Zhiyong Liu, Qianhua Shen, Yiping Tong, Zhixi Tian, Daowen Wang, Aimin Zhang, Xiangqi Zhang, Baoge Zhu
SCIENTIFIC STEERING COMMITTEE
CHAIR: Weihua Wu
VICE CHAIR: Daowen Wang
MEMBERS: Xiangdong Fu, Zhikang Li, Hongqing Ling, Bao Liu, Xu Liu, Shiping Wang, Yongbiao Xue, Hongquan Yang, Fusuo Zhang, Yuxian Zhu
SCIENTIFIC ADVISORY COMMITTEE: Rongxiang Fang, Tingyun Kuang, Zhensheng Li
 
MAJOR RESEARCH PROGRESSES
In 2016, PCCE made significant progresses in the research of genomics, genome editing, yield and quality improvement, plant disease resistance, mineral nutrient efficiency, chromosome engineering and molecular design for breeding of new varieties on the major crops such as wheat, rice, corn and soybean. PCCE published 51 papers, authorized 11 patents, applied 6 PCT patents, authorized 6 crop variety protections, and approved 2 new wheat varieties. The varieties of wheat, corn and soybean bred by PCCE were cultivated more than 180,000 ha in 2016. The representative achievements are as
follows:
 
Genomics: Zhixi Tian’s group studied the co-evolution of miRNAs and their target genes during soybean domestication and found that the evolution of miRNAs was faster than that of their target genes (Liu et al., Plant J, 2016).
 
Genome Editing: Caixia Gao’s group accomplished transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA (Zhang et al., Nat Commun, 2016). In addition, they also achieved in gene replacement and insertion by intron targeting using CRISPR-Cas9 in rice (Li et al., Nat Plants, 2016).
 
Crop Yield and Quality Improvement: Yunhai Li’s group confirmed that SAP was an F-box protein forming part of a SKP1/ Cullin/F-box E3 ubiquitin ligase complex, and functioned in the control of organ size by promoting the proliferation of meristemoid cells (Wang et al., Nat Commun, 2016). They also illustrated that the OsGRF4 regulated by OsmiR396 was involved in grain size and yield control of rice (Duan et al., Nat Plants, 2016). Xigan Liu’s group demonstrated that FHY3 activated SEP2 via inhibiting CLA3 to regulate meristem determinacy and maintenance (Li et al., PNAS, 2016). Cuimin Liu’s group illustrated the crystal structure of Chlamydomonas chloroplast chaperonin homo-oligomer (CPN60β1), and analyzed the functional partition of Cpn60α and Cpn60β subunits in substrate recognition and cooperation with co-chaperonins (Zhang et al. BMC Biol, 2016; Zhang et al., Mol Plant, 2016). Aimin Zhang’s group constructed a high resolution linkage map of einkorn wheat and characterized QTLs controlling seed size with it (Yu et al., Theor Appl Genet, 2016).
 
Plant Disease Resistance: Qianhua Shen’s group collaborated with Qi Xie’ group identified a new E3 ligase which affected the NLR receptor stability and immunity to powdery mildew (Wang et al., Plant Physiol, 2016). Dingzhong Tang’s group revealed that the mutation of glucosinolate biosynthesis enzyme cytochrome P450 83A1 monooxygenase increased camalexin accumulation and powdery mildew resistance (Liu et al., Front Plant Sci, 2016). Daowen Wang’s group analyzed coexpression network of the genes regulated by the two types of resistance responses to powdery mildew in wheat (Zhang et al., Sci Rep, 2016). Zhiyong Liu’s group fine mapped the spot blotch resistance gene Sb3 in wheat (Lu et al., Theor Appl Genet, 2016).
 
Mineral Nutrient Efficiency: Xiangdong Fu’s group illustrated that the shoot-to-root mobile transcription factor HY5 coordinated plant carbon and nitrogen acquisition (Chen et al., Curr Biol, 2016). Yiping Tong’s group proved that knocking out of TaPHO2-A1 was able to improve phosphate uptake and grain yield under low phosphorus conditions in common wheat (Ouyang et al., Sci Rep, 2016). Hong-Qing Ling’s group characterized the AtSPX3 promoter and elucidated its complex regulation in response to phosphorus deficiency (Li et al., Plant Cell Physiol, 2016).
 
Chromosome Engineering and breeding of New Varieties: Fangpu Han’s group demonstrated de novo centromere formation and centromeric sequence expansion in wheat and its wide hybrids (Guo et al., PLoS Genet, 2016). Junming Li’s group bred the wheat varieties “Kenong 2009” and “Kenong 2011”, and they have been approved by National variety committee and the variety committee of Hebei province, respectively. Zhensheng Li’s group and Huabang Chen’s group bred the wheat and corn varieties for the Bohai Granary Science and Technology Demonstration Project.